ZM323881
Product Name： ZM323881
CAS號：193001-14-8
分子式：C22H18FN3O2
分子量：375.4
貯存： 儲存溫度-20°C
可溶性： DMSO
生化和生理學機理：
ZM323881 is a potent and selective inhibitor of human vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) activity. ZM323881 selectively inhibits VEGFR-2 (IC50 = 2 nM) over VEGFR-1 and a range of other receptor tyrosine kinases such as PDGFRβ, FGFR1, EGFR and erbB2 (IC50 > 50 μM). ZM323881 inhibits VEGF-A-induced endothelial cell proliferation in vitro (IC50 = 8 nM).
